Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival
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چکیده
منابع مشابه
Is Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-Analysis
Background: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard. The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. Methods:...
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In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
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Telomere length reflects lifetime cumulative oxidative stress from environmental exposures, such as cigarette smoking and chronic inflammation. Shortened telomere length is thought to cause genomic instability and has been associated with several cancers. We examined the association of telomere length in peripheral leukocyte DNA with gastric cancer risk as well as potential confounding factors ...
متن کاملLeukocyte Telomere Length and Cancer Risk: A Dynamic Problem
Telomeres are the protective structure at both ends of each chromoThe decelerating age-adjusted LTL attrition in cancer cases as they some. Telomere length is widely considered a marker of biological aging. For convenience, telomere lengths in human population studies have been predominately measured in peripheral blood leukocytes. Although leukocyte telomere length (LTL) is generally inversely...
متن کاملLeukocyte telomere length in relation to pancreatic cancer risk: a prospective study.
BACKGROUND Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk; the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. ...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2019
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-19-0577